Progesterone is a key hormone that plays many important roles in the female reproductive system and pregnancy.

What Does Progesterone Do?

Some of the main functions of progesterone include:

  • Preparing the uterus for pregnancy each month as part of the menstrual cycle
  • Maintaining a pregnancy by supporting the developing fetus
  • Preventing the muscles of the uterus from contracting until the end of pregnancy

During the menstrual cycle, progesterone is released after ovulation occurs. It helps prepare and maintain the lining of the uterus, called the endometrium, for a potential pregnancy.

If an egg is fertilized, progesterone levels remain elevated throughout pregnancy to stop contractions of the uterine muscles. This prevents miscarriage and early labor. Progesterone relaxes smooth muscle tissue throughout the body, including the uterine and gastrointestinal tract.

Where Does Progesterone Come From?

In females, progesterone is produced mainly by the corpus luteum and placenta:

  • The corpus luteum forms on the ovary after ovulation. It secretes progesterone to prepare for pregnancy.
  • If pregnancy occurs, the role of progesterone production shifts to the placenta. Levels continue rising exponentially.

During the last few weeks of a full-term pregnancy, progesterone levels decline sharply. This signals the uterus to start contracting and initiates labor.

Some progesterone is also produced by the adrenal glands and in certain areas of the brain.

When Is Progesterone Prescribed?

Doctors may prescribe progesterone supplements in certain situations like:

  • Treating irregular menstrual cycles
  • Preventing miscarriage or early birth
  • Part of hormone therapy during menopause

Progesterone creams, injections, vaginal gels, and intrauterine devices may be given depending on the treatment goal.

I hope this gives you a good overview explaining what progesterone is, its major functions, where it comes from, and when it may be prescribed!

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